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This whitepaper describes the complexity associated with scheduling biomanufacturing operations and presents the idea of "variability aware, always feasible" scheduling. We describe the need for scheduling that envisages the complete manufacturing system including upstream, downstream, resources, interdependencies, process support groups, ancillary staff, engineering and maintenance. A sophisticated scheduling system must also accommodate inherent biological variability which forces schedulers to continually re-plan as campaigns evolve to meet changing conditions in multi-product manufacturing facilities.
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